Markers of Progression from Latent to Active Tuberculosis

An RNA signature found in whole blood can identify people with latent TB who are at risk for progression to active disease.

Of the one third of the global population infected with Mycobacterium tuberculosis, 5% to 10% will progress to active tuberculosis (TB), yet we currently lack tools to identify these individuals before they develop disease progression.

To identify potential biomarkers of TB progression, investigators prospectively collected blood samples from healthy South African adolescents with latent TB and monitored them for progression to active disease. By performing whole blood RNA sequencing on the samples and comparing results from individuals who progressed versus those who remained healthy over a 2-year period, the researchers identified a 16-gene signature of risk for progression to TB disease. They validated the signature in other cohorts of So…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Markers of Progression from Latent to Active Tuberculosis

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Reviewing Author