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Multiple clinical predictors of short-term outcomes for severe peptic ulcer bleeding (PUB) have been identified. Factors that affect longer-term (30-day) outcomes are less well studied.
In a prospective cohort study, investigators assessed 30-day rebleeding, mortality, and surgery in 1264 patients with endoscopically proven PUB, of whom 688 (55%) had stigmata of recent hemorrhage (SRH) at initial endoscopy and received endoscopic therapy.
Results were as follows:
Within 30 days of diagnostic endoscopy, rebleeding occurred in 224 patients (18%), 84 (7%) required surgery, and 91 (7%) died.
Rebleeding was positively associated with ulcer size (a 6% increase in rebleeding occurred for every 10% increase in diameter for ulcers ≥10 mm), major SRH, in…