Symptoms Inadequately Predict Biologic Response in Eosinophilic Esophagitis

A validated patient-reported symptom score predicted endoscopic and histologic remission endpoints with 60% to 70% accuracy.

Symptom severity is not consistently concordant with histologic activity in eosinophilic esophagitis (EoE), making it difficult for clinicians to decide on management strategies based solely on symptom assessment.

In an industry-funded study, investigators in Switzerland and the U.S. prospectively evaluated the ability of a validated symptom-based score (Eosinophilic Esophagitis Activity Index Patient-Reported Outcomes [EoE PRO]), to predict histologic and endoscopic remission in 269 adults with EoE (67% men; mean age, 39 years). The researchers assessed endoscopic findings using the validated EoE Endoscopic Reference Score and conducted histologic assessment of at least four biopsies each from the distal and proximal esophagus. All endoscop…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors