VGKC-Complex Antibodies in the Absence of LGI1 and Caspr2 Antibodies

Most of these patients do not have a clear autoimmune neurological syndrome.

Voltage-gated potassium channel (VGKC) complex antibodies are associated with several autoimmune neurological syndromes, including limbic encephalitis, neuromyotonia, and Morvan syndrome. Many patients formerly said to have “VGKC-complex” antibody–associated limbic encephalitis have antibodies not to the channel itself but rather to the associated channel complex leucine-rich glioma-inactivated protein 1 (LGI1) or contactin-associated protein-like 2 (Caspr2) proteins. LGI1 antibodies are associated with limbic encephalitis, whereas Caspr2 antibodies are more strongly associated with Morvan, neuromyotonia, and presence of a thymoma. Many patients with VGKC-complex antibodies do not have LGI1 or Caspr2 antibodies, however, and the clinical si…

Reviewing Author

Jeffrey M. Gelfand, MD

Disclosures

12/1/14I recently attended a trial investigator meeting as a sub-investigator for a clinical trial sponsored by Medimmune.

Jeffrey M. Gelfand, MD

Disclosures

12/1/14I recently attended a trial investigator meeting as a sub-investigator for a clinical trial sponsored by Medimmune.

VGKC-Complex Antibodies in the Absence of LGI1 and Caspr2 Antibodies

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Reviewing Author