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Previous trials have shown mixed results on the effectiveness of cognitive behavioral therapy (CBT) for the treatment of depression in youth. However, CBT is one of few alternatives to antidepressant medications, which adolescents often refuse to take or fail to take as directed.
Researchers tested a CBT intervention in a primary care setting among 212 adolescents aged 12 to 18 years (68% female) who had previously declined antidepressants to treat major depression. Participants were randomized to CBT (two 4-session modules) plus usual self-selected care (comprising different chosen therapies, including antidepressants in some) or usual self-selected care alone. Patients were followed up for 2 years, and the primary outcome was time to recov…