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Visceral hypersensitivity is an important mechanism of irritable bowel syndrome (IBS). Transient reporter potential channel V1 (TRPV1) is a nociceptor that responds to capsaicin and other noxious stimuli. Sensitization of the TRPV1 receptor has been documented in some pain syndromes and could be induced by mast cell mediators including histamine. Researchers examined this hypothesis and tested a histamine receptor H1blocker in patients with IBS in a multiphase study.
In phase one of the study, rectal biopsy specimens from 9 patients with IBS and 12 healthy control patients were studied. In vitro analyses showed that TRPV1 was sensitized in the patients with IBS, the sensitization was mediated by the effects of histamine on its receptor, and …