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Short-term studies have suggested links between night shift rotation and risk for coronary heart disease (CHD). Now, extended findings from the prospective Nurses' Health Studies (NHS, baseline age range, 30–55; and NHS2, baseline age range, 25–42; all participants female, primarily white), confirm this association. History of working ≥3 night shifts monthly (in addition to day and evening shifts) was assessed at baseline and subsequent intervals.
During 24 years of follow-up, 73,623 NHS participants and 115,535 NHS2 participants without baseline CHD experienced a total of 10,822 events (myocardial infarction, coronary artery bypass graft, angioplasty, coronary artery stent, and angina pectoris). Compared with women who never performed night…