Oral Antibiotics for Infective Endocarditis?

Switching to oral antibiotics after IV induction therapy for a median 21 days was not associated with worse outcomes in uncomplicated cases of IE.

Although treatment guidelines for infective endocarditis (IE) uniformly recommend intravenous (IV) administration of antibiotic therapy, successful oral treatment of Staphylococcus aureus right-sided IE has been reported in case series and one small clinical trial. Now, French researchers have evaluated outcomes in 426 patients (median age, 64) treated for IE at their institution from 2000 through 2012.

Streptococci, S. aureus, and Enterococci accounted for 40%, 19%, and 12% of cases, respectively. Treatment followed the European IE guidelines except that switching to oral antibiotics was allowed after 7 days of IV therapy if the patient's general condition had improved (normalized temperature, leukocytosis, creatinine levels, and C-reactive…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Oral Antibiotics for Infective Endocarditis?

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Reviewing Author