Testing for Cure of Anogenital Gonorrhea

In a prospective study, both RNA- and DNA-based nucleic acid amplification tests were negative in 95% of participants by 6 and 9 days, respectively.

Diagnosis of gonorrhea is recommended to be based not on culture, but on nucleic acid amplification tests (NAATs). Concerns about antimicrobial resistance and asymptomatic infection have led to a call for a test of cure (TOC) to monitor treatment outcome. Because data using NAATs to ascertain TOC are limited, Dutch investigators conducted a prospective cohort study to assess the appropriate timing of TOC using NAATs after treatment of anogenital gonorrhea. In 2014, 62 adults with anogenital gonorrhea self-collected pretreatment anal, vaginal, or urine samples for RNA- and DNA-based NAATs. After treatment with a single intramuscular dose of 500-mg ceftriaxone, participants collected samples from the same anatomical site for the next 28 days.…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Testing for Cure of Anogenital Gonorrhea

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Reviewing Author