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Zika virus (ZIKV) is a newly recognized cause of congenital infection, and reports of affected infants with microcephaly and associated brain and ocular abnormalities are increasing from endemic areas in South America.
In a cross-sectional study, researchers examined factors associated with ocular abnormalities among 40 infants with microcephaly and presumed ZIKV infection born in the Brazilian state of Pernambuco between May and December 2015. Other congenital infections and causes of microcephaly were ruled out. Results were as follows:
Of the 40 infants who underwent ocular examination, just over half (22) had ocular abnormalities; these were bilateral in 68.2%, and both macular and optic nerve alterations were noted.
Of 24 infants who unde…