Risk Factors for Progression to Gastric Adenocarcinoma in the U.S.

Data support targeted surveillance based on risk factors, which included presence of dysplasia and Hispanic ethnicity.

Studies of the progression of gastric intestinal metaplasia (IM) and low-grade dysplasia (LGD) to gastric adenocarcinoma conducted in other countries may not be generalizable to the U.S. population.

In the current study, investigators retrospectively reviewed data from approximately 3.4 million patients enrolled in a regional U.S. healthcare system. All patients with upper endoscopy findings of premalignant gastric lesions between 1997 and 2006 were followed through 2013, including 4146 patients with IM, 141 with LGD, and 44 with high-grade dysplasia (HGD).

Within the first year, 59.1% of patients with HGD developed adenocarcinoma. With a follow-up of 24,440 person-years after the first year, 17 patients with IM (0.4%; 0.72/1000 patient-years…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Risk Factors for Progression to Gastric Adenocarcinoma in the U.S.

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Reviewing Author