Low-Dose Aspirin and Novel Oral Anticoagulants Are Associated with Complications after Polyp Resection

In a population-based study, researchers retrospectively evaluated risk factors for complications from colorectal polyp resection in 345,546 patients in Japan.

Endoscopic mucosal resection (EMR) was performed in 64%, polypectomy in 32%, and endoscopic submucosal dissection (ESD) in 5%. The overall rates of bleeding (postprocedure and requiring endoscopic hemostasis or transfusion), surgically treated bowel perforation, cardiovascular events, cerebrovascular events, and deaths per 1000 patients were 32.5, 0.5, 0.05, 0.9, and 1.3, respectively.

In a multivariate analysis, bleeding risk was positively associated with male gender, various comorbidities (heart failure, cerebrovascular disease, dementia, chronic lung disease, rheumatoid disease, pe…