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In the current population-based study from Alberta, Canada, researchers examined risk for Clostridium difficile infection and its effect on outcomes in ulcerative colitis (UC), following 1754 patients with a new diagnosis of UC. Patients with a prior diagnosis of C. difficile infection were excluded.
The 5-year cumulative risk for developing C. diff infection in the cohort was 3.4%. The remaining results, adjusted for disease severity, were as follows:
The 1-, 3- and 5-year colectomy rates among those with no diagnosis of C. diff infection after UC diagnosis were 5%, 11%, and 13%, respectively, and among the group with a C. diff infection, the rates were 19%, 27%, and 29%, respectively.
Five-year mortality after UC diagnosis was 4% among all p…