Gradual Withdrawal of Desmopressin Is Best After Successful Enuresis Treatment

Compared with abrupt withdrawal, structured withdrawal of desmopressin has significantly better relapse-free rates in children with enuresis.

Desmopressin is an effective treatment for childhood enuresis; however, the preferred method of discontinuation after successful therapy is uncertain.

In a systematic review, researchers identified 601 studies related to efficacy of desmopressin for pediatric enuresis but found only 4 randomized, controlled trials (including 500 patients total) with adequate methodological rigor and data on withdrawal strategies. They conducted a meta-analysis of these trials to compare the efficacy of structured versus abrupt withdrawal of desmopressin following successful therapy for enuresis.

Structured withdrawal of desmopressin was associated with a significantly better relapse-free response compared with abrupt withdrawal (pooled relative risk, 1.38). I…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Gradual Withdrawal of Desmopressin Is Best After Successful Enuresis Treatment

Topics

Reviewing Author