Mild Neurologic Manifestations Are Common in Acute HIV Infection

Symptoms such as cognitive troubles, bradykinesia of hands and fingers, and distal sensory neuropathy were common but transient.

Although various neurologic syndromes occur during acute HIV infection, systematic evaluation of neurologic involvement early in infection has not been performed. To address this gap, investigators prospectively assessed adults with laboratory-confirmed acute HIV infection (Fiebig stages I–V) using structured interviews and neurologic evaluations at diagnosis (study entry), and at 4 and 12 weeks after combination antiretroviral therapy (ART) initiation.

Over half (53%) of 139 participants (93% men; median age, 28 years; mean estimated HIV infection duration, 19 days) with complete neurologic data had one or more neurologic findings determined by self-report or exam. Most (96%) of the 245 total neurologic findings observed over 12 weeks were …

Reviewing Author

Felicia Chow, MD, MAS

Mild Neurologic Manifestations Are Common in Acute HIV Infection

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Reviewing Author