Loading...
Knee osteoarthritis (OA) is a common form of OA, with a prevalence of 37% in people older than 60. Pain associated with knee OA can be exacerbated by the presence of effusions, which stretch the joint capsule and cause discomfort.
Researchers randomized 200 patients (age, >40) who met American College of Rheumatology criteria for knee OA and had new-onset joint effusions (duration, <3 weeks) to one of four treatment groups: spironolactone (50 mg daily), ibuprofen (400 mg thrice daily), cold compresses (10 minutes twice daily), or placebo tablets (once daily) for 2 weeks. Patients who received spironolactone were hospitalized for the first 3 days, and all patients had electrolyte values measured daily for the first 3 days.
Spironolactone patie…