Risk-Reducing Salpingo-Oophorectomy and BRCA: Retain the Uterus?

Multicenter study suggests that hysterectomy should be encouraged in BRCA mutation carriers.

In women who harbor BRCA mutations, risk-reducing salpingo-oophorectomy (RRSO) is routinely recommended to lower risk for ovarian and breast cancer — but whether this surgery should include hysterectomy remains unclear. Investigators prospectively evaluated risk for uterine cancer in BRCA1 and BRCA2 mutation carriers who underwent RRSO without hysterectomy at one of nine centers in the U.S. or U.K. and compared this risk with expected rates from national surveillance data. Observed-to-expected (O:E) ratios (similar to relative risk) were calculated.

Among 1083 women (median age at RRSO, 46; median follow-up, 5 years), 8 incident uterine cancers occurred (expected incidence, 4.3; O:E ratio, 1.9; P=0.09). In analysis stratified by tumor subtyp…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Risk-Reducing Salpingo-Oophorectomy and BRCA: Retain the Uterus?

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Reviewing Author