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An increasing number of patients with hepatitis C virus (HCV) infection are being cured with new, more-effective treatment regimens, yet long-term clinical monitoring for such patients remains unclear. Achieving sustained virologic response (SVR) has been shown to reduce risk for hepatocellular carcinoma (HCC), but the magnitude of that risk reduction is undetermined.
In a large retrospective study of patients in the U.S. Veterans Affairs healthcare system, researchers assessed risk for and predictors of developing HCC among 10,738 patients who received treatment for HCV infection with interferon-based regimens and achieved SVR.
Among these patients (95% men, 64% white), 100 incident cases of HCC were identified, for an annual incidence of 0.…