A large study revealed no increase in Alzheimer disease pathology with history of a traumatic brain injury with loss of consciousness.
Traumatic brain injury (TBI) has been associated with the subsequent development of Alzheimer disease (AD) in several studies using clinical, not pathology-based, diagnoses. These researchers analyzed data from three large, longitudinal, prospective studies (N=7130; baseline mean age, 80; 2879 men; follow-up, 45,190 person-years) to examine links between TBI with loss of consciousness (LOC) and late-life clinical findings of neurodegenerative disorders or neuropathologic findings at autopsy.
History of a head injury was reported by 865 participants; 213 had neuropathological evaluations at autopsy. TBI with LOC was not associated with elevated dementia risk (AD or minimal cognitive impairment), even after APOE genotype was included. However,…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)