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Evidence is limited on efficacy of atypical antipsychotics in post-traumatic stress disorder (PTSD). The 2010 practice guideline from the Department of Veterans Affairs (VA) and Department of Defense did not recommend monotherapy (http://www.healthquality.va.gov/guidelines/MH/ptsd/), although it allowed consideration of low-dose risperidone and quetiapine. The quetiapine recommendation was based on a single open-label trial for patients not responding to selective serotonin or norepinephrine–serotonin reuptake inhibitors (SSRIs/SNRIs). This industry-funded, two-site, 12-week, VA-based study randomized 80 patients with chronic military PTSD (mean age, 53; 94% men; 53% white) to flexibly dosed quetiapine (starting dose, 25 mg/day; by 2 weeks,…