Despite inconsistencies among different sets of criteria, some diagnostic indicators are critical.
The serotonin syndrome (SS) can result from overstimulation of 5-HT1A and 5-HT2 receptors, as manifested by neuromuscular hyperexcitability (such as myoclonus, tremor, hyperreflexia). Because SS can occur with commonly used psychiatric drugs (selective serotonin reuptake inhibitors [SSRIs], migraine medications, opiates), it is important for clinicians to recognize it early. Several classification systems for SS (i.e., Sternbach, Radomski, and Hunter) have been published. Now, researchers have conducted a meta-analysis of 299 adult cases in the literature to compare these sets of criteria.
Topics included how SS compared with neuroleptic malignant syndrome (NMS) and whether hyperthermia was a necessary criterion. Much of the information abou…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)