Modeling study suggests policies advocating pregnancy delay could actually exacerbate risk for Zika-related microcephaly.
Officials in several Latin American countries have recommended pregnancy delay to avoid prenatal Zika exposure during early gestation. Using demographic data from Colombia, researchers modeled the impact of such pregnancy delay on vector-borne Zika transmission.
Assuming 50% adherence to the recommendation, a delay of 9 to 24 months may decrease prenatal Zika infections by 17% to 44%. However, a delay of ≤6 months may increase such infections by 2% to 7%. The reason for this potential increase is that the postponed pregnancies may coincide with the peak of the epidemic, thereby increasing the number of women at risk for having a child with microcephaly or other Zika-related abnormalities.
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)