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Fecal transplant is the best available treatment for refractory or recurrent Clostridium difficile infection (CDI), but it is often problematic to arrange, and its safety can be hard to guarantee. Entrepreneurs are scrambling to devise safer and more convenient variants with similar efficacy. One proposed alternative is SER-109, a suspension of healthy donor stool mixed with 100% alcohol and incubated to remove bacterial cells and leave only spores behind. Washed, resuspended in glycerol, and stored in capsules at –80° C, the preparation contains gram-positive spores (including Bacilli and Clostridia) with no living or vegetative gram negatives.
In an exploratory, manufacturer-sponsored, open-label, single-arm study, 30 patients with recurre…