IVF in PCOS: Are Frozen Embryos Better Than Fresh?

In a randomized trial, live-birth rates were higher and risk for ovarian hyperstimulation syndrome was lower following frozen-embryo transfer.

Women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) have excess risk for ovarian hyperstimulation syndrome (OHSS) after fresh-embryo transfer. Investigators in China conducted a trial of fresh- versus frozen-embryo transfer to determine if use of frozen embryos would augment live-birth rates and lower risk for treatment-related complications in 1508 women (age range, 20–34) with PCOS undergoing their first IVF cycle. Participants were randomized to fresh-embryo transfer or embryo cryopreservation with transfer during a subsequent controlled cycle. After 3 days in culture, up to two fresh or frozen embryos were transferred.

Use of frozen embryos yielded higher live-birth rates after the first transfer than did …

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

IVF in PCOS: Are Frozen Embryos Better Than Fresh?

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Reviewing Author