Early Noninvasive Surfactant Administration Techniques May Improve Outcomes in Preterm Babies

These techniques were associated with the lowest risk for death or BPD compared with other ventilation strategies.

In some systematic reviews, data show that early nasal continuous positive airway pressure (CPAP) use reduces the composite outcome of death or bronchopulmonary dysplasia (BPD) compared with early intubation in preterm infants. Fewer data are available on the effect of early surfactant administration using the techniques of INSURE (INtubation and SURfactant followed by immediate Extubation) or LISA (Less Invasive Surfactant Administration, in which surfactant is instilled into the trachea by a feeding tube, without intubation).

In a systematic review, researchers identified 30 published trials involving 5598 infants that compared two or more of seven commonly used ventilation strategies for premature babies, including mechanical ventilation,…

Reviewing Author

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Early Noninvasive Surfactant Administration Techniques May Improve Outcomes in Preterm Babies

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Reviewing Author