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Proton-pump inhibitors (PPIs) are used routinely after endoscopic submucosal dissection (ESD) for early gastric cancer to reduce bleeding and promote healing of ESD-induced gastric ulcers. To compare the effectiveness of vonoprazan, a potassium-competitive acid blocker, and PPIs in this setting, investigators in a single center in Japan administered vonoprazan (20 mg/day) to 75 patients for 5 weeks starting the day before ESD. They compared post-procedure rates of bleeding and ulcer healing with those of a historic cohort of matched controls treated with a PPI (20 mg, twice daily for the first 2 days, then once daily) for 8 weeks starting after ESD. Endoscopic ulcer healing was determined at 5 weeks in the vonoprazan group and at 8 weeks in…