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Fecal microbiota transplantation (FMT) has become the treatment of choice for multiple recurrences of Clostridium difficile infection (CDI), based on numerous case series showing high recurrence rates after continued antibiotic therapy and high cure rates after FMT.
The current study is the first randomized, blinded, controlled trial of FMT for recurrent CDI. In two centers, 46 patients with three or more recurrences and who had received at least a full course of vancomycin for their most recent acute episode were randomized to receive donor FMT or autologous FMT administered by colonoscopy. Donors were healthy volunteers or individuals chosen by patients, and all underwent infection screening before donating.
The cure rate was 91% with donor…