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Data from recent trials favor pancolonic chromoendoscopy and targeted biopsy rather than four-quadrant random biopsy in ulcerative colitis.
In the current study, 246 patients from 34 Japanese centers were randomized to targeted biopsy without chromoendoscopy or random biopsy. High-definition colonoscopy was employed at the endoscopist's discretion and based on availability; the exact frequency of its use was not specified. Chromoendoscopy was used in both arms if a lesion was identified, and targeted biopsy was encouraged in the random arm as appropriate.
The average number of biopsy samples with dysplasia per colonoscopy was similar in the targeted and random groups (0.211 and 0.168, respectively), as was the detection rate of patients with …