Breast Cancer Risk from Atypical Ductal Hyperplasia in the Modern Era

Ten-year risk for invasive breast cancer after a diagnosis of ADH might be lower than previously reported.

Atypical ductal hyperplasia (ADH) is a proliferative breast lesion that is diagnosed in about 100,000 women per year in the U.S., most often by stereotactic biopsy of suspicious microcalcifications identified at mammography. Risks for subsequent invasive carcinoma after ADH diagnosis were previously reported to be as high as 20% to 30% during long-term follow-up. However, these estimates were determined prior to widespread use of screening mammograms and core needle biopsies to evaluate suspicious lesions.

To update these estimates, investigators conducted a cohort study involving nearly 1 million women who underwent screening mammography between 1996 and 2012. Of these, 1727 had ADH, which was diagnosed by core needle biopsy in 61% and by e…

Reviewing Author

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)