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A colorectal cancer (CRC) risk calculator from the National Cancer Institute (NCI) incorporates risk factors — sex, current age, body-mass index, vegetable intake, use of aspirin or nonsteroidal anti-inflammatory drugs, level of exercise, previous CRC screening, smoking history, and estrogen status (in women) — in addition to family history. In this study, researchers determined whether the NCI calculator's predicted 10-year CRC risk would correlate with the presence of advanced neoplasia in 509 people who underwent screening colonoscopy. The definition of advanced neoplasia included tubular adenoma ≥10 mm, villous or tubulovillous adenoma, adenoma with high-grade dysplasia, and several other categories.
Among people whose calculator-predict…