Adverse CV Event Rates According to Achieved Systolic BP in Patients with Coronary Artery Disease

Optimal target blood pressure (BP) for hypertensive patients remains controversial. Investigators analyzed primary adverse cardiovascular outcome events (CV-related death, myocardial infarction, or stroke) among >22,000 patients in a multinational observational database who had stable coronary artery disease (CAD) and hypertension and were treated with at least one antihypertensive drug at baseline. For each patient, the mean of annual resting BP measurements was calculated for 5 years or until a first adverse cardiovascular (CV) event.

Compared with patients who had mean systolic BP of 120 to 129 mm Hg, those with lower or higher mean systolic BPs were significantly more likely to experience a primary outcome (hazard ratios, 1.56, 1.51, and…