Adherence to Preexposure Prophylaxis Among Young, Nonwhite HIV-Uninfected MSM

Young black and Latino men who have sex with men (MSM) have the highest risk for HIV infection in the U.S. However, preexposure prophylaxis (PrEP) is approved only for people aged >18 years, and PrEP studies have rarely included young, nonwhite MSM. Investigators from the Adolescent Trials Network conducted a 48-week open-label PrEP demonstration and safety study that enrolled young MSM in 12 U.S. urban centers.

Of 2186 men screened, 200 (median age, 20 years; 55% black, 27% Latino) were eligible and willing to participate; 81% reported condomless sex in the past month. The study-retention rate was 71%. Participants received a standard PrEP regimen, with monthly check-ins through week 12 and quarterly through week 48.

All three grade 3 advers…