Kidney-Related Cardiovascular Risk Increases as HIV-Positive People Age

The link between renal impairment and cardiovascular disease (CVD) in HIV-infected people has been suggested but not definitively established. Using longitudinal data from more than 35,000 HIV-positive people (48% white; 74% male; median age, 41 years) in the ongoing prospective, multinational D:A:D cohort study, investigators analyzed the relationship between estimated glomerular filtration rate (eGFR), measured by the Cockcroft–Gault method, and a first CVD event.

During a median 8 years of follow-up, 1646 centrally adjudicated CVD events occurred in 1357 persons. After 5 years, incident CVD was significantly more common among HIV-positive people with diminished eGFR, most notably among those with eGFR ≤30 mL/min/1.73m² compared with those…