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The diagnosis of multiple sclerosis (MS) is clinical and relies on expert neurological evaluation, accurate interpretation of magnetic resonance imaging (MRI) findings, and targeted exclusion of other potential causes. Now, four academic MS centers provide pooled data on MS misdiagnosis, defined as a firm diagnosis of MS from another physician for a patient subsequently given an alternate revised diagnosis (presumed to be correct) after evaluation in an MS specialty center.
Of 110 patients misdiagnosed with MS, 70% had received MS immunomodulatory therapy and 4% had enrolled in MS clinical treatment trials. One quarter of MS misdiagnoses were made by neurologists with MS-focused practices. The most common alternate diagnoses were migraine (2…