Proton Pump Inhibitors Linked to Fundic Gland Polyps

PPI use has an association with FGPs that increases with the duration of therapy.

Fundic gland polyps (FGPs) are a common incidental finding at upper endoscopy. An association between FGPs and the use of proton pump inhibitors (PPIs) has long been suggested, but good data have been lacking.

To further explore the potential link between FGPs and PPIs, investigators in Australia conducted a meta-analysis of 12 studies (involving 39,671 participants) that included data on the prevalence of FGPs in PPI users versus nonusers.

The number of FGPs was significantly greater in PPI users than in nonusers (odds ratio, 2.46; 95% confidence interval, 1.42–4.27). The association increased with duration of PPI use (OR, 4.71; 95% CI, 2.22–9.99 for ≥6 months of therapy, and OR, 5.32; 95% CI, 2.58–10.99 for ≥12 months of therapy). The autho…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Proton Pump Inhibitors Linked to Fundic Gland Polyps

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Reviewing Author