An analysis of observational data links low diastolic blood pressures to increased risk for heart disease in people with systolic blood pressures ≥120, raising questions about the impact of medically lowering SBP.
With all the attention on target systolic blood pressure (SBP), diastolic blood pressure (DBP) is often relegated to a footnote. However, there are concerns that lowering a patient's SBP may affect coronary perfusion pressure by reducing the DBP. Investigators evaluated possible links of DBP to adverse outcomes and myocardial damage in an analysis of 21 years of data from the ARIC study, a prospective observational cohort.
Of the 11,565 adults studied here, 57% were female, and 25% were black (mean baseline age, 57). Participants with the two lowest levels of DBP (<60 mm Hg and 60–69 mm Hg) were more likely than those with DBPs of 80 to 89 mm Hg to have a high-sensitivity cardiac troponin-T (hs-cTNT) level ≥14 ng/L. DBPs <65 mm Hg had a line…
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DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association