Hepatitis B and C infections are associated with an increased risk for NHL in HIV-infected patients.
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections have been associated with an increased risk for non-Hodgkin lymphoma (NHL) in HIV-uninfected populations, perhaps because of abnormal immune stimulation or B-cell proliferation.
To determine whether HIV-infected patients face a similar increased risk, European investigators analyzed data from 52,479 treatment-naive HIV-infected patients in an observational cohort study (COHERE) who were tested for HBV and HCV infection. Of these patients, 40,219 (77%) subsequently initiated antiretroviral therapy (ART). The study focused on patients seen between 2000 and 2013.
NHL developed in 252 ART-naive and 310 ART-treated patients. Among ART-treated patients, development of NHL was si…
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)