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In a review on monitoring disease activity in inflammatory bowel disease (IBD), the following are some key clinical points:
The Crohn disease activity index (CDAI) correlates poorly with endoscopic findings.
Symptoms correlate better with endoscopic findings in ulcerative colitis (UC) compared with Crohn disease (CD), though symptoms are imperfect indicators in both diseases.
Magnetic resonance imaging and ultrasound are both good tests for disease activity in ileocolonic CD. Ultrasound is less costly and does not require contrast, though in the U.S., technical expertise to perform ultrasound in CD is lacking.
In about 20% of people, C-reactive protein (CRP) is not expressed in inflammatory conditions; this is genetically determined. Checking C…