Preventing Post-ERCP Pancreatitis: IV Fluids to the Rescue?

Vigorous hydration with lactated Ringer's solution was superior to standard hydration in preventing post–endoscopic retrograde cholangiopancreatography pancreatitis.

Pilot study data suggest a possible role for aggressive intravenous (IV) fluid resuscitation in preventing post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Use of lactated Ringer's solution has been shown to be better than normal saline in treatment of acute pancreatitis.

In a randomized, controlled trial from three high-volume ERCP centers in Korea, researchers randomized patients aged 18–75 years to receive vigorous (3 mL/kg/hour) or standard (1.5 mL/kg/hour) IV hydration with lactated Ringer's solution during the procedure and for 8 hours after. Patients receiving vigorous hydration also received pre- and postprocedure boluses of 10 mL/kg. All patients were receiving their first ERCP (native papilla), did not have …

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors