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Standard chemotherapy for esophageal and gastroesophageal junction adenocarcinoma mirrors that for gastric cancer and typically combines a fluorinated pyrimidine with a platinum agent, yet there is ongoing controversy about the relative benefit of triplet versus doublet chemotherapy and whether or not anthracyclines should be included in combination chemotherapy regimens.
Investigators now report the results of a network meta-analysis of the safety and efficacy of first-line chemotherapy for esophagogastric cancer. The analysis evaluated 17 chemotherapy regimens received by more than 10,000 patients in 50 studies, including 34 that directly compared chemotherapy regimens in nearly 7800 patients.
Pooled direct and indirect comparisons indicate…