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The role of adjuvant chemotherapy or radiation therapy for patients with resected gallbladder cancer remains controversial, as mixed conclusions have been drawn from largely uncontrolled, retrospective studies.
Investigators have now used data from the National Cancer Database to study more than 8500 patients (70% female; median age, 72) who underwent curative resection for gallbladder cancer at more than 1500 facilities from 2004 through 2011. Of these patients, 16% had T1 disease, 36% had T2 disease, 21% had T3 disease, and 26% had node-positive disease. Also, 46% of patients underwent laparoscopic surgery, 42% underwent open surgery, and 12% converted from laparoscopic to open surgery.
Adjuvant chemotherapy was given to 29% of patients, of…