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In 2005, researchers from the Rotterdam Study (a long-term prospective cohort study of various aspects of aging) reported the prevalence of incidental findings in 2000 middle-aged and older adults who underwent routine brain magnetic resonance imaging (MRI; NEJM JW Gen Med Dec 1 2007 and N Engl J Med 2007; 357:1821). A decade later, the researchers have expanded their database: They now report incidental brain MRI findings in 5800 participants, a majority of whom underwent two or three MRIs at several-year intervals. Mean age at initial imaging was 65.
The prevalence of at least one incidental finding of potential clinical relevance was 10%; the most common such findings were meningiomas (2.5%), cerebral aneurysms (2.3%), arachnoid cysts (1.…