Cervical Intraepithelial Neoplasia Treatment and Pregnancy Outcome: The Method Matters

Excisional treatment of CIN was associated with excess risk for preterm birth.

To assess the impact of cervical intraepithelial neoplasia (CIN) treatment on pregnancy outcomes, investigators in Norway utilized national health registries to examine birth outcomes in 943,321 singleton pregnancies (545,243 women) between 1998 and 2014. In all, 9554 women received CIN treatment prior to pregnancy (mean 4.3 years from treatment to childbirth). Hazard ratios were adjusted for factors such as maternal age, parity, and smoking status.

The most common treatments were excisional (e.g., loop electrosurgical excision procedures [LEEP; 46%], laser conization [38%], needle diathermy excision [14%]). Few women underwent nonexcisional treatments (laser vaporization [1.0%], cryotherapy [0.3%]). Women who had excisional CIN treatment ha…

Reviewing Author

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Cervical Intraepithelial Neoplasia Treatment and Pregnancy Outcome: The Method Matters

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Reviewing Author