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Myasthenia gravis (MG) is twice as common in women as in men and usually affects women in the second and third decade of life, overlapping with peak childbearing years. The disease is exacerbated during pregnancy in one third of patients. The course of MG in pregnancy is unpredictable. However, exacerbation in puerperium is more likely to occur in patients with shorter history of the disease (Eur J Obstet Gynecol Reprod Biol 2002; 104:21).
To study the risk for clinical onset of MG in pregnant women and during the first 6 months postpartum, researchers conducted a cross-sectional, population-based cohort study of two MG cohorts from Norway, the regions of south Holland, and parts of north Holland. A total of 1038 healthy controls from Norway…