Acute Kidney Injury Is Common in Critically Ill Children

Severe AKI developed in 11.6% of children and young adults admitted to critical care units and was associated with increased risk for death.

Acute kidney injury (AKI) is associated with adverse outcomes in critically ill adults. In a prospective multinational study, researchers examined the association between AKI and mortality at 28 days in 4683 critically ill children and young adults (age, 3 months to 25 years) admitted to 32 pediatric critical care units. AKI was considered severe if the serum creatinine level increased to at least twice baseline or urine output was <0.5 ml/kg per hour for ≥12 hours.

AKI developed in 26.9% of patients and was severe in 11.6%. Relying on serum creatinine alone would have missed the diagnosis of AKI in 67.2% of patients who met the urine output criteria. Patients with severe AKI had significantly higher mortality than those without severe AKI (…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Acute Kidney Injury Is Common in Critically Ill Children

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Reviewing Author