Prediabetes Is Associated with Excess Cardiovascular Risk

The extent to which prediabetes predisposes people to adverse cardiovascular (CV) outcomes is unclear. A reason for inconsistent findings might be the varied definitions for prediabetes:

• The American Diabetes Association (ADA) defines prediabetes as impaired fasting glucose (100–125 mg/dL), impaired glucose tolerance (2-hour glucose level of 140–199 mg/dL during an oral glucose tolerance test), or glycosylated hemoglobin (HbA_1c) level of 5.7% to 6.4%.

• Compared with the ADA definitions, the World Health Organization and the U.K. National Institute for Health and Care Excellence (UK NICE) use a higher threshold for impaired fasting glucose (110 mg/dL).

• Compared with the ADA definitions, UK NICE uses higher values for HbA_1c (6.0%–6.4%).

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