Early-Onset Neonatal Sepsis in the Era of GBS Prophylaxis

Rates of E. coli sepsis remain stable despite prevalent intrapartum Group B Streptococcus prophylaxis.

The incidence of early-onset neonatal sepsis due to group B Streptococcus (GBS) has declined significantly following the implementation of intrapartum prophylaxis. Initial surveillance reports raised concerns that screening and prophylaxis for GBS would result in an increased burden of antibiotic-resistant Escherichia coli neonatal sepsis. In the current study, investigators reviewed 10 years of population-based surveillance data on invasive bacterial infections in infants aged 0–2 days born in 208 hospitals in four U.S. regions.

During 2005 through 2014, 1484 cases of early-onset neonatal sepsis were identified. GBS and E. coli were the most frequently identified organisms (36% and 25%, respectively). The overall incidence of sepsis was sta…

Reviewing Author

Deborah Lehman, MD

Disclosures

Nothing to disclose

Deborah Lehman, MD

Disclosures

Nothing to disclose

Early-Onset Neonatal Sepsis in the Era of GBS Prophylaxis

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Reviewing Author