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Some evidence suggests that testosterone use, which has risen dramatically in recent years, is associated with elevated risk for venous thromboembolism (VTE). In this population-based case-control study, researchers in the U.K. examined data on more than 2 million men to evaluate risk for VTE associated with testosterone treatment — especially the timing and duration of treatment. About 19,200 men with confirmed VTE (8400 with deep venous thrombosis; 10,800 with pulmonary embolism) were identified and matched by age and VTE risk factors with 910,000 controls; mean age of participants was 65.
Adjusted for multiple factors, risk for VTE was 25% higher with current testosterone use than with no testosterone use. Current testosterone use for 6 m…