Following the roll-out of antiretroviral therapy in a rural South African community, tuberculosis and HIV-related mortality declined, and life expectancy increased.
Several reports have demonstrated that antiretroviral therapy (ART) substantially decreases morbidity and mortality in people living with HIV. These authors analyzed HIV-associated mortality and population-level life expectancy in a community-based cohort of 93,903 adults in a rural community in KwaZulu-Natal, South Africa, after initiation of a public sector ART program (535,428 person-years of observation and 9992 deaths between 2001 and 2014).
For the total community population, the death rate decreased from 23.1 (95% confidence interval, 22.3–23.9) per 1000 person-years between 2001 and 2004 to 13.6 (13.0–14.2) per 1000 person-years between 2011 and 2014. Between 2003 and 2014, life expectancy of adult men and women increased by 15.2 yea…
Reviewing Author
DisclosuresConsultant/Advisory BoardUNAIDS; WHO; Bill and Melinda Gates Foundation, Population Council
Grant/Research SupportNIH; National Institute of Allergy and Infectious Diseases; Tides Foundation/MAC AIDS Fund; USAID; South African National Research Foundation; European Union; South African Medical Research Council
Editorial BoardsNew England Journal of Medicine; AIDS Reviews; AIDS Research and Human Retroviruses; mBio; Indian Journal of Medical Research; JAIDS: Journal of Acquired Immune Deficiency Syndromes
DisclosuresConsultant/Advisory BoardUNAIDS; WHO; Bill and Melinda Gates Foundation, Population Council
Grant/Research SupportNIH; National Institute of Allergy and Infectious Diseases; Tides Foundation/MAC AIDS Fund; USAID; South African National Research Foundation; European Union; South African Medical Research Council
Editorial BoardsNew England Journal of Medicine; AIDS Reviews; AIDS Research and Human Retroviruses; mBio; Indian Journal of Medical Research; JAIDS: Journal of Acquired Immune Deficiency Syndromes