Oral Therapies for Managing Type 2 Diabetes in Adults: An Updated Guideline

Metformin continues to be recommended as first-line therapy — and it might be prescribed safely to some patients with lower glomerular filtration rates.

Sponsoring Organization: American College of Physicians (ACP)

Target Audience: All clinicians

Background

In the U.S., 12 drug classes are approved for treating patients with type 2 diabetes. However, data to guide selection of agents are sparse. To fill this gap, the ACP has updated its 2012 guideline on the comparative effectiveness and safety of oral medications for type 2 diabetes in adults (Ann Intern Med 2012; 156:218). Recommendations are based on a systematic review of randomized trials and observational studies published through December 2015. Evaluated medications were metformin, thiazolidinediones, sulfonylureas, dipeptidyl peptidase (DPP)-4 inhibitors, and sodium-glucose cotransporter (SGLT)-2 inhibitors.

Key Points

Lowering glycosyla…

Reviewing Author

Jamaluddin Moloo, MD, MPH

Disclosures

Grant / Research supportColorado Health Foundation